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Modulating fatty acid metabolism and composition of CHO cells by feeding high levels of fatty acids complexed using methyl-β-cyclodextrin

https://doi.org/10.1016/j.ymben.2025.04.005

Priem, Bradley; Cai, Xiangchen; Hong, Yu-Jun; Gilmore, Karl; Deng, Zijun; Chen, Sabrina; Naik, Harnish Mukesh; Betenbaugh, Michael J; Antoniewicz, Maciek R (September 2025, Metabolic Engineering)

Free, publicly-accessible full text available September 1, 2026
Ala-Cys-Cys-Ala dipeptide dimer alleviates problematic cysteine and cystine levels in media formulations and enhances CHO cell growth and metabolism

https://doi.org/10.1016/j.ymben.2024.07.008

Ladiwala, Pranay; Cai, Xiangchen; Naik, Harnish Mukesh; Aliyu, Lateef; Schilling, Martin; Antoniewicz, Maciek R; Betenbaugh, Michael J (September 2024, Metabolic Engineering)

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Elucidating uptake and metabolic fate of dipeptides in CHO cell cultures using 13C labeling experiments and kinetic modeling

https://doi.org/10.1016/j.ymben.2024.03.002

Naik, Harnish Mukesh; Cai, Xiangchen; Ladiwala, Pranay; Reddy, Jayanth Venkatarama; Betenbaugh, Michael J; Antoniewicz, Maciek R (May 2024, Metabolic Engineering)

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Generation of reference cell lines, media, and a process platform for CHO cell biomanufacturing

https://doi.org/10.1002/bit.28290

Cordova, Lauren T.; Dahodwala, Hussain; Elliott, Kathryn S.; Baik, Jongyoun; Odenewelder, Daniel C.; Nmagu, Douglas; Skelton, Bradley A.; Uy, Lisa; Klaubert, Stephanie R.; Synoground, Benjamin F.; et al (December 2022, Biotechnology and Bioengineering)

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